DIAGNOSTIC CHALLENGES OF SINGLE PLAQUE-LIKE LESION PAUCIBACILLARY LEPROSY

The diagnosis of single-lesion paucibacillary leprosy remains a challenge.Reviews by expert dermatopathologists and quantitative polymerase chain Fitness reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared.Histological findings were graded as high (HP), medium (MP) or low (LP) probability of leprosy or other dermatop

Mycolactone, the amphiphilic macrolide toxin secreted by Mycobacterium ulcerans, plays a significant role in the pathology and manifestations of Buruli ulcer (BU).Consequently, it follows that the toxin is a suitable target for the development of diagnostics and therapeutics for this disease.Yet, several challenges have deterred such development.Fo